David R. Rubinow, MD
Assad Meymandi Distinguished Professor and Chair
Department of Psychiatry
Professor of Medicine
Director, Innovation and Entrepreneurship
School of Medicine
University of North Carolina at Chapel Hill
Reproductive Mood Disorders: This is Your Brain on Steroids
This talk will explore the role of reproductive steroids in the regulation of affective state.
Dr. David Rubinow is the Assad Meymandi Professor and Chair of the Department of Psychiatry at the University of North Carolina – Chapel Hill, School of Medicine. Prior to joining UNC, he was the Clinical Director of the National Institute of Mental Health (NIMH) and Chief of the Behavioral Endocrinology Branch. His research interests focus on neurobehavioral effects of gonadal steroids and how genetic variation contributes to differential behavioral response to changes in steroid signaling. Research methods used include administration of hormone super agonists and receptor blockers to manipulate the menstrual cycle and identify the central effects of gonadal steroids in isolation. These studies have demonstrated that, unlike mood disorders accompanying endocrinopathies, reproductive endocrine-related mood disorders represent abnormal responses to normal hormonal signals. Current NIH funded studies include investigations of continuous oral contraceptive administration in menstrual cycle-related mood disorders, estradiol effects on cardiovascular risk and mood dysregulation during the perimenopause, and biomarkers of postpartum depression. Additionally, the UNC Women’s Mood Disorders Program, which he directs, has the first and only NIH training fellowship in Women’s Mood Disorders. On the basis of his research, he was inducted into the Institute of Medicine of the National Academies in 2012. Dr. Rubinow is also the Director of the UNC Center for Innovation and Health Care System Transformation, which promotes the development of patient-centered innovations designed to address the current challenges facing our nation’s health care delivery system.